Structural and biophysical methods for biological macromolecules in solution
Singapore • 06 – 14 December 2017
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About the course:
Structural methods applicable to solutions facilitate structural and functional studies on biological macromolecules under close to native conditions. Fully exploiting this opportunity allows one to extract the maximum amount of biologically meaningful information and to relate the structural results to the function of the system. The main objective of this EMBO course is to train graduate students and postdocs in state-of-the-art methods to study biological macromolecules in solution. We aim at a comprehensive coverage of the major structural and biophysical techniques employed for characterization of high and low resolution structure and structural transitions, macromolecular complex formation, protein folding, stability, interactions and enzymatic mechanisms.The EMBO course will include lectures on:
Small-angle X-ray and neutron scattering (SAXS/SANS)
Nuclear magnetic resonance (NMR)
Light scattering, hydrodynamic, calorimetric and spectroscopic approaches.
Cryo-electron microscopy (cryoEM)
Bioinformatic tools to analyse protein-protein interactions
Macromolecular crystallography (MX)
Special attention will be paid to interdisciplinary approaches, where the synergistic use of complementary techniques leads to a comprehensive description of macromolecular systems.SELECTION CRITERIA
Preference will be given to applicants active in structural biology, mostly late PhD students and early postdocs. However, more senior scientists, depending on circumstances will be considered. Non-academic applicants are also encouraged to apply.
Registration for the course will include accommodation and meals:
€1000 (Industry)DEADLINE for registration:
01 September 2017